Journal
ANNALS OF NEUROLOGY
Volume 80, Issue 6, Pages 797-810Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.24793
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Funding
- RSNA Resident/Fellow Scholar Award
- NIH [U24DA041123, R01NS035129]
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Malformations of cortical development (MCDs) compose a diverse range of disorders that are common causes of neurodevelopmental delay and epilepsy. With improved imaging and genetic methodologies, the underlying molecular and pathobiological characteristics of several MCDs have been recently elucidated. In this review, we discuss genetic and molecular alterations that disrupt normal cortical development, with emphasis on recent discoveries, and provide detailed radiological features of the most common and important MCDs.
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