Journal
FUTURE ONCOLOGY
Volume 15, Issue 15, Pages 1697-1705Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2018-0874
Keywords
chemoradiotherapy; chemotherapy; financial toxicity; lung cancer; non-small-cell lung cancer; quality of life; radiation therapy
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Funding
- Radiation Oncology Institute [ROI20162-913]
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Aim: Financial toxicity (FT) describes patients' burden from out-of-pocket medical treatment costs. We studied associations between patient-reported pretreatment FT, socioeconomic status and clinical outcomes for locally advanced non-small-cell lung cancer (LA-NSCLC) patients. Methods: Patients received chemoradiotherapy for locally advanced non-small-cell lung cancer and completed the European Organization for the Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C30) quality of life assessment before treatment. One question asks whether patients experience financial difficulties'. We tested FT and socioeconomic status (SES) as predictors of progression-free survival (PFS) and overall survival (OS). Results: A total of 43 patients were included. Median follow-up for surviving patients was 15 months. A total of 19 patients (44%) experienced disease progression and 17 patients (40%) died. Increasing FT was associated with shorter PFS (p=0.011). FT did not predict overall survival (p=0.67). Conclusion: Higher pretreatment FT is associated with shorter PFS.
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