Journal
ANNALS OF NEUROLOGY
Volume 80, Issue 1, Pages 160-165Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.24679
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Funding
- Joint Programming for Neurodegenerative Disease (JPND)
- JPND
- Chief Scientific Office, Scotland
- Department of Health
- Scottish Home Office Department of Health
- MRC [MR/J016071/1] Funding Source: UKRI
- Chief Scientist Office [ETM/58] Funding Source: researchfish
- Medical Research Council [MR/J016071/1] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [26305030, 15H04269] Funding Source: KAKEN
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Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice.
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