Journal
ANNALS OF NEUROLOGY
Volume 80, Issue 3, Pages 443-447Publisher
WILEY-BLACKWELL
DOI: 10.1002/ana.24718
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Funding
- Guthy-Jackson Charitable Foundation
- National Multiple Sclerosis Society [RG 4768]
- Valhalla Foundation
- Alexander M. and June L. Maisin Foundation of the Jewish Community Federation
- Endowment Fund
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T cells from neuromyelitis optica (NMO) patients, which recognize the immunodominant epitope of aquaporin-4, exhibit Th17 polarization and cross-react with a homologous sequence of a Clostridium perfringens adenosine triphosphate-binding cassette transporter. Therefore, this commensal microbe might participate in NMO pathogenesis. We examined the gut microbiome by PhyloChip G3 from 16 NMO patients, 16 healthy controls (HC), and 16 multiple sclerosis patients. A significant difference in the abundance of several microbial communities was observed between NMO and HC (Adonis test, p=0.001). Strikingly, C. perfringens was overrepresented in NMO (p=5.24x10(-8)). These observations support a potential role for C. perfringens in NMO pathogenesis. Ann Neurol 2016;80:443-447
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