Journal
FUNGAL GENETICS AND BIOLOGY
Volume 126, Issue -, Pages 12-16Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.fgb.2019.01.013
Keywords
Endosome; FYVE; PAM2; RNA transport; RNA recognition motif
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Funding
- Deutsche Forschungsgemeinschaft, Germany (DFG, German Research Foundation) [FE448/10-1 DFG-FOR2333, DFG-CRC1208, 267205415, CEPLAS EXC1028]
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Active movement of mRNAs by sophisticated transport machineries determines precise spatiotemporal expression of encoded proteins. A prominent example discovered in fungi is microtubule-dependent transport via endosomes. This mode of transport was thought to be only operational in the basidiomycete Ustilago maydis. Here, we report that distinct core components are evolutionarily conserved in fungal species of distantly related phyla like Mucoromycota. Interestingly, orthologues of the key RNA-binding protein Rrm4 from the higher basidiomycete Coprinopsis cinerea and the mucoromycete Rhizophagus irregularis shuttle on endosomes in hyphae of U. maydis. Thus, endosomal mRNA transport appears to be more wide-spread than initially anticipated.
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