Journal
FUNGAL BIOLOGY
Volume 124, Issue 5, Pages 253-262Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.funbio.2019.04.001
Keywords
ROS sensing; Fungal development; Reactive oxygen species; Secondary metabolism; Virulence
Categories
Funding
- CONACYT grants Investigacion en Fronteras de la Ciencia [2015-I-319]
- CONACYT-DFG [277869]
- PAPIIT-UNAM [IN200719, IV200519]
- Brazilian agency CAPES [88887.289326/2019-00]
- Brazilian agency FAPESP [2018/20571-6]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/20571-6] Funding Source: FAPESP
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The regulation of gene expression in response to increased levels of reactive oxygen species (ROS) is a ubiquitous response in aerobic organisms. However, different organisms use different strategies to perceive and respond to high ROS levels. Yeast Yap1 is a paradigmatic example of a specific mechanism used by eukaryotic cells to link ROS sensing and gene regulation. The activation of this transcription factor by H2O2 is mediated by peroxiredoxins, which are widespread enzymes that use cysteine thiols to sense ROS, as well as to catalyze the reduction of peroxides to water. In filamentous fungi, Yap1 homologs and peroxiredoxins also are major regulators of the antioxidant response. However, Yap1 homologs are involved in a wider array of processes by regulating genes involved in nutrient assimilation, secondary metabolism, virulence and development. Such novel functions illustrate the divergent roles of ROS and other oxidizing compounds as important regulatory signaling molecules. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of British Mycological Society.
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