Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 135, Issue -, Pages 60-67Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2019.02.018
Keywords
Fasting; Oxidative stress; Mitochondrial dysfunction; Fibrosis; Ischemia-reperfusion injury; Acute kidney injury; Chronic kidney disease
Funding
- Consejo Nacional de Ciencia y Tecnologia (CONACyT, Mexico) [220646]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica (PAPIIT, Mexico) [IN201316]
- Programa de Apoyo a la Investigacion y Posgrado (PAIP, Mexico) [5000-9105]
- Fondos del Gasto Directo autorizado a la Subdireccion de Investigacion basica
- CONACyT
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Food deprivation protects against ischemia-reperfusion (IR) injury through unknown mechanisms. In an experimental rat model of acute IR injury, we found that preoperative fasting for 3 days protects rats from tubular damage and renal functional decline by increasing antioxidant protection independently of the NF-E2-related factor 2 (Nrf2), and by maintaining mitochondrial morphology and function. In addition, further analysis revealed that fasting protects against tubulointerstitial fibrosis. In summary, our results point out to fasting as a robust nutritional intervention to limit oxidative stress and mitochondrial dysfunction in early acute kidney injury and also to promote long-term protection against fibrosis.
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