Related references
Note: Only part of the references are listed.Shared links between type 2 diabetes mellitus and Alzheimer's disease: A review
Khyati Mittal et al.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2016)
A neglected modulator of insulin-degrading enzyme activity and conformation: The pH
Giuseppe Grasso et al.
BIOPHYSICAL CHEMISTRY (2015)
Modulation of insulin degrading enzyme activity and liver cell proliferation
Olga Pivovarova et al.
CELL CYCLE (2015)
Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo
Timothy B. Durham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Impaired insulin action in the human brain: causes and metabolic consequences
Martin Heni et al.
NATURE REVIEWS ENDOCRINOLOGY (2015)
Accumulation of BRI2-BRICHOS ectodomain correlates with a decreased clearance of Aβ by insulin degrading enzyme (IDE) in Alzheimer's disease
M. Del Campo et al.
NEUROSCIENCE LETTERS (2015)
Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment
Xiaohua Li et al.
CLINICAL INTERVENTIONS IN AGING (2015)
Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis
Huawei Cheng et al.
INTERNATIONAL JOURNAL OF NEUROSCIENCE (2015)
Impact of Insulin Degrading Enzyme and Neprilysin in Alzheimer's Disease Biology: Characterization of Putative Cognates for Therapeutic Applications
Niraj Kumar Jha et al.
JOURNAL OF ALZHEIMERS DISEASE (2015)
Brain metabolic dysfunction at the core of Alzheimer's disease
Suzanne M. de la Monte et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis
Julie Charton et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2014)
Mechanisms and Effects of Curcumin on Spatial Learning and Memory Improvement in APPswe/PS1dE9 Mice
Pengwen Wang et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2014)
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones
Juan Pablo Maianti et al.
NATURE (2014)
Neuropep-1 ameliorates learning and memory deficits in an Alzheimer's disease mouse model, increases brain-derived neurotrophic factor expression in the brain, and causes reduction of amyloid beta plaques
Min-Kyoo Shin et al.
NEUROBIOLOGY OF AGING (2014)
Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease
Liang Hong et al.
NEUROLOGICAL RESEARCH (2014)
The role of glucagon on type 2 diabetes at a glance
Amelio F. Godoy-Matos
DIABETOLOGY & METABOLIC SYNDROME (2014)
Nonsteroidal Selective Androgen Receptor Modulators and Selective Estrogen Receptor β Agonists Moderate Cognitive Deficits and Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
Sonia George et al.
ACS CHEMICAL NEUROSCIENCE (2013)
Sevoflurane alters the expression of receptors and enzymes involved in A clearance in rats
Y. Liu et al.
ACTA ANAESTHESIOLOGICA SCANDINAVICA (2013)
The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of α-Synuclein Levels in β-Cells
Par Steneberg et al.
DIABETES (2013)
Hepatic Insulin Clearance Is Closely Related to Metabolic Syndrome Components
Olga Pivovarova et al.
DIABETES CARE (2013)
Propranolol reduces cognitive deficits, amyloid and tau pathology in Alzheimer's transgenic mice
Marta Dobarro et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)
Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity
Samer O. Abdul-Hay et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease
Yunyun Zhang et al.
NEUROSCIENCE LETTERS (2013)
Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme
Bilal Cakir et al.
PLOS ONE (2012)
Cell-Permeable, Small-Molecule Activators of the Insulin-Degrading Enzyme
Sayali S. Kukday et al.
JOURNAL OF BIOMOLECULAR SCREENING (2012)
Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?
Kawser Akter et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2011)
Possible implications of insulin resistance and glucose metabolism in Alzheimer's disease pathogenesis
Domenico Bosco et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)
Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance
Samer O. Abdul-Hay et al.
PLOS ONE (2011)
Identification of the Allosteric Regulatory Site of Insulysin
Nicholas Noinaj et al.
PLOS ONE (2011)
Insulin metabolism in human adipocytes from subcutaneous and visceral depots
Janet Fawcett et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Changes with Age in the Activities of β-Secretase and the Aβ-Degrading Enzymes Neprilysin, Insulin-Degrading Enzyme and Angiotensin-Converting Enzyme
J. Scott Miners et al.
BRAIN PATHOLOGY (2010)
Norepinephrine Promotes Microglia to Uptake and Degrade Amyloid β Peptide through Upregulation of Mouse Formyl Peptide Receptor 2 and Induction of Insulin-Degrading Enzyme
Yan Kong et al.
JOURNAL OF NEUROSCIENCE (2010)
How does diabetes accelerate Alzheimer disease pathology?
Catrina Sims-Robinson et al.
NATURE REVIEWS NEUROLOGY (2010)
Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aβ, and Alzheimer's Disease
Minerva M. Carrasquillo et al.
PLOS ONE (2010)
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
Malcolm A. Leissring et al.
PLOS ONE (2010)
Non-viral causes of hepatocellular carcinoma
Wojciech Blonski et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2010)
A PPARdelta Agonist Reduces Amyloid Burden and Brain Inflammation in a Transgenic Mouse Model of Alzheimer's Disease
Sergey Kalinin et al.
CURRENT ALZHEIMER RESEARCH (2009)
Glucose inhibits the insulin-induced activation of the insulin-degrading enzyme in HepG2 cells
O. Pivovarova et al.
DIABETOLOGIA (2009)
Somatostatin: A Novel Substrate and a Modulator of Insulin-Degrading Enzyme Activity
Chiara Ciaccio et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes
Natalia Rudovich et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2009)
Neprilysin and Insulin-Degrading Enzyme Levels Are Increased in Alzheimer Disease in Relation to Disease Severity
James Scott Miners et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
The proteasomal system
Tobias Jung et al.
MOLECULAR ASPECTS OF MEDICINE (2009)
Small-Molecule Activators of Insulin-Degrading Enzyme Discovered through High-Throughput Compound Screening
Christelle Cabrol et al.
PLOS ONE (2009)
Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease
Natalia N. Nalivaeva et al.
CURRENT ALZHEIMER RESEARCH (2008)
Stem cell antigen-1 localizes to lipid microdomains and associates with insulin degrading enzyme in skeletal myoblasts
Conrad L. Epting et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Regulation of protein degradation by insulin-degrading enzyme: Analysis by small interfering RNA-mediated gene silencing
Janet Fawcett et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase
Nidhi Ahuja et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families
Minji Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek et al.
NATURE (2007)
Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease
Zhong Zhao et al.
NEUROBIOLOGY OF AGING (2007)
Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells
F. G. Hamel et al.
DIABETES OBESITY & METABOLISM (2006)
Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism
Yuequan Shen et al.
NATURE (2006)
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease:: review and hypothesis
WQ Qiu et al.
NEUROBIOLOGY OF AGING (2006)
Autophagy and signaling: their role in cell survival and cell death
P Codogno et al.
CELL DEATH AND DIFFERENTIATION (2005)
Is insulin signaling molecules misguided in diabetes for ubiquitin-proteasome mediated degradation?
M Balasubramanyam et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2005)
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid β-protein
W Farris et al.
BIOCHEMISTRY (2005)
Age- and region-dependent alterations in Aβ-degrading enzymes:: implications for Aβ-induced disorders
A Caccamo et al.
NEUROBIOLOGY OF AGING (2005)
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease - is this type 3 diabetes?
E Steen et al.
JOURNAL OF ALZHEIMERS DISEASE (2005)
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid β-protein
W Farris et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients
NN Rudovich et al.
DIABETES (2004)
Quantitative trait loci near the insulin-degrading enzyme (IDE) gene contribute to variation in plasma insulin levels
HF Gu et al.
DIABETES (2004)
Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: Implications for Alzheimer's disease intervention
LX Zhao et al.
JOURNAL OF NEUROSCIENCE (2004)
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria
MA Leissring et al.
BIOCHEMICAL JOURNAL (2004)
Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death
MA Leissring et al.
NEURON (2003)
Substrate activation of insulin-degrading enzyme (insulysin) - A potential target for drug development
ES Song et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell cultures
RG Bennett et al.
DIABETES (2003)
Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease:: evidence of effect modification by apolipoprotein E (APOE)
SD Edland et al.
NEUROSCIENCE LETTERS (2003)
Non-covalent interaction of ubiquitin with insulin-degrading enzyme
T Saric et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2003)
Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme
RG Bennett et al.
JOURNAL OF ENDOCRINOLOGY (2003)
Polymorphisms in the insulin-degrading enzyme gene are associated with type 2 diabetes in men from the NHLBI Framingham Heart Study
S Karamohamed et al.
DIABETES (2003)
In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters
FG Hamel et al.
ENDOCRINOLOGY (2003)
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
W Farris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats
H Fakhrai-Rad et al.
HUMAN MOLECULAR GENETICS (2000)
Degradation of soluble amyloid β-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains
A Pérez et al.
NEUROCHEMICAL RESEARCH (2000)
Share Paper
