Journal
FITOTERAPIA
Volume 134, Issue -, Pages 201-209Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2019.02.013
Keywords
bird's nest fungus; Cyathane diterpenoids; Neurotrophic activity; Anti-neuroinflammatory activity; Molecular docking
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Funding
- National Natural Science Foundation of China [21572182, 81502938]
- Shangluo University [17SKY013]
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Eleven new cyathane diterpenoids, designated cyafricanins A-K (1 - 11), were isolated from the culture broth of the baisidiomycete Cyathus africanus (Nidulariaceae, Bird's nest fungi). Their structures were elucidated by comprehensive analysis of their NMR and HRESIMS data. Cyafricanins A (1) was found to possess an unusual 3,4-seco-carbon skeleton. All compounds were evaluated for their neurotrophic activity in PC-12 cells and antineuroinflammatory activity in BV2 microglia cells. All of the diterpenoids showed nerve growth factor induced neurite outgrowth-promoting activity at concentration of 20 mu M. Among them, cyafricanin B (2) and cyafricanin G (7) exhibited promising neurotrophic activity, and cyafricanin A (1) showed strong inhibitory effects on both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Furthermore, molecular docking studies revealed that cyafricanin A (1) showed strong interactions with the iNOs protein in the active cavity.
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