Journal
FEMS MICROBIOLOGY LETTERS
Volume 366, Issue 10, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnz112
Keywords
Clostridium perfringens; tectorigenin; type IV pilus system; gliding motility; biofilm formation; adherence
Categories
Funding
- National Natural Science Foundation of China [31772782, 31602109]
- National Key Research and Development Program of China [2018YFD0500300]
- Fundamental Research Funds for the Central University
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Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans and animals around the globe. The type IV pilus (TFP) system plays a key role in the colonization and invasion of host cells, biofilm formation and gliding motility, which is vital for C. perfringens infection. Therefore, targeting TFP function may be a promising strategy for the treatment of C. perfringens infection. Here, we investigated the potential inhibitory effects of tectorigenin (TE), an isoflavone extracted from the rhizome of the Chinese herb Belamcanda chinensis (L.) DC, on gliding motility, biofilm formation, adherence to cells and antibacterial activity of C. perfringens. Tectorigenin significantly inhibited gliding motility, biofilm formation and adherence to Caco-2 cells without observable antibacterial activity against C. perfringens. In addition, we also demonstrated that the inhibitory effect of TE on TFP function appears to be partially achieved by the suppression of TFP-associated genes. These findings demonstrate that TE may have the potential to be developed as a new anti-virulence drug for C. perfringens infection, particularly for the targeting of TFP.
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