Journal
FAMILIAL CANCER
Volume 18, Issue 3, Pages 363-367Publisher
SPRINGER
DOI: 10.1007/s10689-019-00127-7
Keywords
Hereditary diffuse gastric cancer; E-Cadherin; Stomach
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Around 10-20% of gastric cancer patients have relatives with a diagnosis of GC and in 1-3% of patients a genetic cause can be confirmed. Histopathologically, GC is classified into intestinal-type, with glandular growth, and diffuse-type with poorly cohesive growth pattern often with signet ring cells. Familial or hereditary GC is classified into hereditary diffuse GC (HDGC), familial intestinal GC (FIGC) and polyposis forms. This review focuses on recent research findings and new concepts of hereditary GC.
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