Journal
EXPERIMENTAL DERMATOLOGY
Volume 28, Issue 12, Pages 1466-1469Publisher
WILEY
DOI: 10.1111/exd.13975
Keywords
ATP; keratinocyte; Merkel cell; nociception; pain; skin; TRPV1
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Recent years have brought an enhanced understanding of keratinocyte contribution to cutaneous nociception. While intra-epidermal nerve endings were classically considered as the exclusive transducers of cutaneous noxious stimuli, it has now been demonstrated that epidermal keratinocytes can initiate nociceptive responses, like Merkel cells do for the innocuous mechanotransduction. In the light of recent in vivo findings, this article outlines this paradigm shift that points to a not yet considered population of sensory epidermal cells.
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