Journal
EXPERIMENTAL CELL RESEARCH
Volume 378, Issue 2, Pages 226-231Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2019.03.011
Keywords
Integrins; Integrin-associated proteins; Extracellular matrix; Mechanotransduction
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Integrin-mediated adhesion to the extracellular matrix involves a surprisingly large number of intracellular proteins, the integrin-associated proteins (IAPs), which are a fraction of the total integrin adhesome. In this review we discuss how genetic approaches have improved our understanding of how each IAP contributes to integrin function, especially in the context of building a functional organism during development. We then begin the process of assembling IAP roles together into an integrated mechanism.
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