Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 20, Pages 3195-3202Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900480
Keywords
C-H activation; Synthetic methods; Alkenylation; Acetoxylation; Palladium catalysis
Categories
Funding
- National Natural Science Foundation of China [21702087, 21801105]
- Natural Science Foundation of Liaoning Province [2015020196, 20170520353, 20180510033]
- Program for Liaoning Innovative Talents in University [LR2017021]
- Research Project Fund of Liaoning Provincial Department of Education [L2017LQN010, L2017LZD001]
- Talent Scientific Research Fund of Liaoning Shihua University [2016XJJ-078, 2016XJJ-079]
- open project of Jilin Province Key Laboratory of Organic Functional Molecular Design Synthesis [130028836]
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Palladium-catalyzed remote meta-selective C-H functionalization of arylacetic acid has been developed using a pyrimidine template. This transformation is not only tolerated to a diverse range of arylacetic acid and alkene substrates but also applicable to the synthesis of pharmaceutically active ibuprofen derivatives. Moreover, the pyrimidine template was readily removable and recyclable under mild conditions.
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