Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2020, Issue 10, Pages 1515-1522Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900611
Keywords
Alkylation; Minisci reaction; Photoredox catalysis; Synthetic methods; Visible light
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The development of a Minisci reaction of electron-deficient heteroarenes with non-activated alkyl bromides under visible-light photoredox catalysis is disclosed. Optimization of the reaction led to identification of mild, general, and practical reaction conditions compatible with sensitive functional groups. The scope of this transformation allowed late-stage functionalization of pharmaceutical products containing electron-deficient heteroarenes in a parallel fashion.
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