Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 17, Pages 2864-2868Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201900290
Keywords
Biocatalysis; Organocatalysis; Trypsin; C-H activation; C-C bond formation
Categories
Funding
- CSIR, New Delhi
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Employment of trypsin for C(sp(3))-H functionalization to construct a new C-C bond utilizing 2-methylbenzothiazole/2-methyl benzoxazole with diones has been explored. This novel and greener approach have been effectively utilized to afford bioactive 3-substituted-3-Hydroxy-2-oxindoles. Furthermore, the presented method combines the enzyme promiscuity and C-H functionalization which open up and expands the repertoire of chemoenzymatic C-H functionalization.
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