Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 49, Issue 8, Pages 1226-1234Publisher
WILEY
DOI: 10.1002/eji.201847858
Keywords
Chronic infection; Interleukin (IL)-10; Regulatory B cells; Schistosoma mansoni; Type I interferons
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Funding
- ZonMW-VIDI grant from Nederlandse Organisatie voor Wetenschappelijk Onderzoek [91714352]
- MRC
- BBSRC
- EPSRC
- MCCIR
- ZonMW-VIDI grant from the Netherlands Organisation for Scientific Research [91714352]
- Netherlands Lung Foundation Accelerate Programme [12017001]
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The helminth Schistosoma mansoni (S. mansoni) induces a network of regulatory immune cells, including interleukin (IL)-10-producing regulatory B cells (Bregs). However, the signals required for the development and activation of Bregs are not well characterized. Recent reports suggest that helminths induce type I interferons (IFN-I), and that IFN-I drive the development of Bregs in humans. We therefore assessed the role of IFN-I in the induction of Bregs by S. mansoni. Mice chronically infected with S. mansoni or i.v. injected with S. mansoni soluble egg antigen (SEA) developed a systemic IFN-I signature. Recombinant IFN-alpha enhanced IL-10 production by Bregs stimulated with S. mansoni SEA in vitro, while not activating Bregs by itself. IFN-I signaling also supported ex vivo IL-10 production by SEA-primed Bregs but was dispensable for activation of S. mansoni egg-induced Bregs in vivo. These data indicate that although IFN-I can serve as a coactivator for Breg IL-10 production, they are unlikely to participate in the development of Bregs in response to S. mansoni eggs.
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