Journal
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
Volume 276, Issue 6, Pages 1685-1691Publisher
SPRINGER
DOI: 10.1007/s00405-019-05379-8
Keywords
Nasal polyp; Chronic rhinosinusitis; Cytokine; Amphiregulin
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Funding
- Adnan Menderes University Research Foundation [TPF-16015]
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ObjectiveChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease. The surrogate indicating biomarkers in patients with CRSwNP need further evaluation. The aim of this study was to investigate the association of thymic stromal lymphopoietin (TSLP) and amphiregulin (AREG) cytokines in patients with CRSwNP.MethodsSinonasal tissue samples were collected from 33 patients with CRSwNP and 29 controls. Levels of AREG, IL-19, IL-21, IL-25, IL-33 and TSLP in nasal polyp and control sinonasal tissues were determined following the enzyme-linked immunosorbent assay method.ResultsWe found that AREG, IL-19, IL-21, IL-25, IL-33 and TSLP levels were significantly higher in the CRSwNP group compared to the control group (p<0.000; p<0.000; p<0.000; p<0.000; p<0.003; p<0.021, respectively).ConclusionsOur findings indicated that AREG, IL-19, IL-21, IL-25, IL-33 and TSLP were significantly increased in tissue samples of CRSwNP patients and may be considered as molecular indicators and targets for therapeutic developments for patients with CRSwNP.
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