Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 70, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.etap.2019.103197
Keywords
COEs; Total antioxidant capacity; GSTM1; Gene polymorphisms
Funding
- National Natural Science Foundation of China [81872597]
- Province Natural Science Foundation of Henan [U170410430]
- Programs for Science and Technology Development of Zhengzhou [121PPTGG503-2]
- Outstanding Youth Grant of Zhengzhou University [1521329035]
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Objectives: The aim of this study was to investigate the association between coke oven emissions (COEs) exposure and total antioxidant capacity (T-AOC), and to explore whether genetic variations in metabolic enzyme genes GSTT1, GSTM1, GSTP1, and CYP2E1 can affect these associations in coke oven workers. Methods: 536 coke oven workers and 238 healthy controls were recruited. T-AOC of plasma was determined with kit. Five polymorphic loci of GSTT1 (+ /-), GSTM1 (+/-), GSTP1 rs1695, CYP2E1 rs6413432 and CYP2E1 rs3813867 were detected by polymerase chain reaction and restriction fragment length polymorphism. Results: This study shows that the T-AOC in exposure group (12.02 +/- 4.72) was significantly lower than that in control group (15.32 +/- 7.19) (P < 0.01), and the COEs exposure could decrease the T-AOC of coke oven workers significantly [beta(95% CI) = -2.663 (-4.538,-0.787), P < 0.001]. The T-AOC of female was lower than that of male in exposed and control groups (P < 0.001). The T-AOC was higher in GSTM1 (-) individuals than in GSTM1 (+) individuals in the control group (P = 0.037). The T-AOC with the AG genotype in GSTP1 rs1695 polymorphism was higher than that of the GG genotype in the control group (P = 0.043). The generalized linear model results showed that the risk factors for the decrease of T-AOC include GSTT1 (+) (b = -0.999, P = 0.009), female (b = -2.875, P < 0.01), COEs-exposed (b = -2.712, P = 0.004), GSTM1 (+) (b = -1.814, P = 0.008), and interactions of GSTM1 (+) and COEs-exposed (b = 1.872, P = 0.024). Conclusions: The risk factors for the decrease of T-AOC include GSTT1 (+), female, COEs-exposed, GSTM1 (+), and interactions of GSTM1 (+) and COEs-exposed.
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