Journal
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
Volume 67, Issue -, Pages 87-93Publisher
ELSEVIER
DOI: 10.1016/j.etap.2019.02.002
Keywords
TBARS; Antioxidant enzymes; ctsk; opa1; pklr
Funding
- project IGA VFU Brno [249/2015/FVHE]
- ERDF/ESF Profish [CZ.02.1.01/0.0/0.0/16_019/0000869]
- Ministry of Education, Youth and Sport of the Czech Republic [LO1218]
- Ministry of Education, Youth and Sports of the Czech Republic [C2.1.05/2.1.00/01.0024, LO1205]
Ask authors/readers for more resources
The purpose of our experiment was to evaluate the effect of enrofloxacin on biotransformation, oxidative stress and mRNA expression of related genes in fish as a non-target organisms. Zebrafish (Danio rerio) juveniles were treated with enrofloxacin at concentrations of 5, 10 and 500 mu g/L for 14 days. A three-day-long test caused changes of catalytic activity of glutathione peroxidase and glutathione-S-transferase. Moreover, lipid peroxidation was observed at the highest concentration. No significant changes either in catalytic activity of antioxidant enzymes or elevated lipid peroxidation were observed from sampling day 7 on. mRNA expression of genes encoding antioxidant enzymes was also not affected by enrofloxacin after a 14-day exposure. This suggests the ability of D. rerio juveniles to adapt to enrofloxacin in a short time period. Moreover, enrofloxacin was not shown to affect collagen, cathepsin K, optic atrophy 1 and pyruvate kinase L/R mRNA expression in this study.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available