Efficacy of simultaneous VEGF-A/ANG-2 neutralization in suppressing spontaneous choroidal neovascularization

This study independently confirms in vivo in the JR5558 mouse model of aberrant retinal angiogenesis, that simultaneous VEGF-A and ANG-2 neutralization using a bispecific anti-VEGF-A/ANG-2 antibody reduces vascular leakage, immune reactivity and apoptosis more effectively than either agent alone.