Journal
ELECTRONIC MATERIALS LETTERS
Volume 15, Issue 4, Pages 471-480Publisher
KOREAN INST METALS MATERIALS
DOI: 10.1007/s13391-019-00141-y
Keywords
Magnetic nanoparticle; Ferrite; Biomolecule; Cellular uptake; Quantitative analysis
Categories
Funding
- National Research Foundation of Korea - Ministry of Science and ICT [2014M3A7B4052193, 2019R1A2C3006587]
- Ministry of Trade, Industry and Energy of Korea under Industrial Technology Innovation Program [10080408]
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education [2017R1D1A1B03036100]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10080408] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2014M3A7B4052193, 2017R1D1A1B03036100, 2019R1A2C3006587] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Due to their ability to be internalized into cells by endocytosis through cell membranes, the application of nanoparticles in therapeutic and diagnostic fields has received much interest. In particular, ferrite magnetic nanoparticles (MNPs) are widely used as reagents for medical care, including in vitro magnetic separation, T2-weighted magnetic resonance imaging, magnetic hyperthermia therapy, and as drug delivery systems. However, little is known about the quantitative analysis of the cellular uptake of MNPs by the interaction of particle surfaces with biomolecules. Here, we quantitatively analyze the intracellular uptakes of 30nm Fe- and Mn-ferrite MNPs. We confirm that the magnetic properties of MNPs change according to their microstructure and quantitatively analyze nanoparticle internalization in breast cell lines (MCF10A, MCF7, and MDA-MB-231) by measuring the magnetic moment using a vibrating sample magnetometer. Finally, we examine the effect of nanoparticle microstructure on cellular uptake in terms of the interaction between the nanoparticles and biomolecules. [GRAPHICS] .
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