Poly(Taurine-Glutathione)/Carbon Nanotube Modified Glassy Carbon Electrode as a New Levofloxacin Sensor

A new highly sensitive and selective electrochemical levofloxacin sensor based on co-polymer-carbon nanotube composite electrode was developed. Taurine and Glutathione were electrochemically co-polymerized on multiwalled carbon nanotubes modified glassy carbon electrode (Poly(TAU-GSH)/CNT/GCE) and used as a levofloxacin sensor in pH 6 phosphate buffer solution. The new composite electrode surfaces were characterized by scanning electron microscopy, atomic force microscopy and electrochemical impedance spectroscopy. Under the optimized conditions, two linear segments were obtained for increasing LEV concentrations between 20 nmol L-1-1 mu mol L-1 and 1.5 mu mol L-1-55 mu mol L-1 LEV with a detection limit of 9 nmol L-1 using amperometry. Poly(TAU-GSH)/CNT/GCE exhibited high sensitivity, selectivity with good stability. The new sensor was employed for real samples of LEV tablets and urine. Promising results were obtained with good accuracy which were also in accordance with LC-MS/MS analysis.