Journal
DNA REPAIR
Volume 76, Issue -, Pages 50-59Publisher
ELSEVIER
DOI: 10.1016/j.dnarep.2019.02.007
Keywords
DNA polymerase; Mutagenesis; Tumorigenesis; Exonuclease proofreading
Categories
Funding
- National Institutes of Health, National Institute of Environmental Health Sciences [R01ES028271]
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DNA polymerases are uniquely poised to contribute to the elevated mutation burdens seen in many human tumors. These mutations can arise through a number of different polymerase-dependent mechanisms, including intrinsic errors made using template DNA and precursor dNTPs free from chemical modifications, misinsertion events opposite chemically damaged template DNA or insertion events using modified nucleotides. While specific DNA repair polymerases have been known to contribute to tumorigenesis, the role of replication polymerases in mutagenesis in human disease has come into sharp focus over the last decade. This review describes how mutations in these replication DNA polymerases help to drive mutagenesis and tumor development, with particular attention to DNA polymerase epsilon. Recent studies using cancer genome sequencing, mutational signature analyses, yeast and mouse models, and the influence of mismatch repair on tumors with DNA polymerase mutations are discussed.
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