Journal
DNA AND CELL BIOLOGY
Volume 38, Issue 7, Pages 597-606Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/dna.2018.4552
Keywords
mitochondrial dysfunction; atherosclerosis; endothelial cell; smooth muscle cell; macrophage
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Mitochondria are highly dynamic organelles beyond powerhouses of a cell. These components also play important roles in cell homeostasis by regulating cell function and phenotypic modulation. Atherosclerosis is the leading cause of morbidity and mortality in developed and developing countries. Mitochondrial dysfunction has been increasingly associated with the initiation and progression of atherosclerosis by elevating the production of reactive oxygen species and mitochondrial oxidative stress damage, mitochondrial dynamics dysfunction, and energy supply. In this review, we describe the progression of the link between mitochondrial dysfunction and atherosclerosis and its potential regulation mechanisms.
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