Journal
DIABETES OBESITY & METABOLISM
Volume 21, Issue 8, Pages 1801-1816Publisher
WILEY
DOI: 10.1111/dom.13760
Keywords
diabetes; diabetic complications; pharmacological mechanisms; prediabetes; randomized controlled trials; traditional Chinese medicine
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Funding
- Special Scientific Research for Traditional Chinese Medicine of China [201507001-11]
- National Natural Science Foundation of China [81274000]
- Young Elite Scientists Sponsorship Program by CAST [2017QNRC1-02]
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Traditional Chinese medicine (TCM) has recorded knowledge of diabetes for over 2000 years. Because a considerable number of TCM studies exhibit design defects, such as limited intervention duration, small sample sizes and inconsistent efficacy evaluations, the role of TCM in the treatment of diabetes cannot be fully elucidated. In this review, we evaluate randomized controlled trials of prediabetes, diabetes and diabetic complications published in the past decade. We found that TCM could significantly improve glucose control and clinical indices in patients with diabetes and effectively delay the progression of diabetes. We also summarize potential pharmacological mechanisms underlying the efficacy of TCM medication/herbs and their active ingredients for treating diabetes. More rigorously designed experiments and long-term evaluation of TCM for diabetes will allow for more effective diabetes management.
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