Journal
DEVELOPMENTAL DYNAMICS
Volume 248, Issue 7, Pages 506-513Publisher
WILEY
DOI: 10.1002/dvdy.64
Keywords
amniotes; anamniotes; Atoh1; cerebellum; Cux2; external granular layer; granule cells
Categories
Funding
- Canadian Institutes of Health Research [PJT-156364]
- Natural Sciences and Engineering Council of Canada [RGPIN-04475-2015]
Ask authors/readers for more resources
The cerebellum coordinates vestibular input into the hindbrain to control balance and movement, and its anatomical complexity is increasingly viewed as a high-throughput processing center for sensory and cognitive functions. Cerebellum development however is relatively simple, and arises from a specialized structure in the anterior hindbrain called the rhombic lip, which along with the ventricular zone of the rostral-most dorsal hindbrain region, give rise to the distinct cell types that constitute the cerebellum. Granule cells, being the most numerous cell types, arise from the rhombic lip and form a dense and distinct layer of the cerebellar cortex. In this short review, we describe the various strategies used by amniotes and anamniotes to generate and diversify granule cell types during cerebellar development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available