Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 25, Issue 6, Pages 700-709Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612825666190408122557
Keywords
Uric acid; hyperuricaemia; cardiovascular diseases; gout; metabolic syndrome; chronic kidney disease
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Funding
- Zhejiang Provincial Science and Technology Plan Project of Traditional Chinese Medicine [2017ZB082]
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Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.
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