Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 58, Issue -, Pages 191-196Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2019.04.001
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Funding
- U.K. Biotechnology and Biological Sciences Research Council (BBSRC) [P024092, J019135]
- BBSRC [BB/F010346/1, BB/P024092/1, BB/J019135/1] Funding Source: UKRI
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Circular dichroism (CD) spectroscopy has been used widely in structural biology for literally a half century, primarily to examine the secondary structure, folding, and interactions of proteins in solution. With recent developments in instrumentation, it is now possible to apply CD to many additional types of sample environments, including oriented membranes, films, and dehydrated samples. In addition, developments in bioinformatics have made validated CD spectra and metadata available for novel analysis methods on additional types of samples such as membrane proteins, intrinsically disordered proteins, multiple fold types, and multicomponent, macromolecular complexes. New software has also enabled increased inter-operability of CD with other structural biology methodologies, contributing to their use in joint studies of protein structures at various levels of organization.
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