Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 55, Issue -, Pages 1-10Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2019.04.013
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Funding
- DFG-Deutsche Forschungsgemeinschaft [NI-1536]
- N.I.H. [GM36477, GM099134]
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Compacted, transcriptionally repressed chromatin, referred to as heterochromatin, represents a major fraction of the higher eukaryotic genome and exerts pivotal functions of silencing repetitive elements, maintenance of genome stability, and control of gene expression. Among the different histone post-translational modifications (PTMs) associated with heterochromatin, tri-methylation of lysine 9 on histone H3 (H3K9me3) is gaining increased attention. Besides its known role in repressing repetitive elements and non-coding portions of the genome, recent observations indicate H3K9me3 as an important player in silencing lineage-inappropriate genes. The ability of H3K9me3 to influence cell identity challenges the original concept of H3K9me3-marked heterochromatin as mainly a constitutive type of chromatin and provides a further level of understanding of how to modulate cell fate control. Here, we summarize the role of H3K9me3 marked heterochromatin and its dynamics in establishing and maintaining cellular identity.
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