Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 49, Issue -, Pages 67-75Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2018.10.004
Keywords
-
Categories
Funding
- NSF, Division of Molecular and Cellular Biosciences [MCB-1513007]
- NSF Graduate Research Fellowship [DGE-1144469]
- Donna and Benjamin M. Rosen Bioengineering Center
- NIH [K99GM129419]
Ask authors/readers for more resources
C-H functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an array of C-H oxidations in biology. Recent work has coupled concepts from synthetic chemistry, computation, and natural product biosynthesis to engineer heme protein systems to deliver products with tailored oxidation patterns. Heme protein catalysis has been shown to go well beyond these native reactions and now accesses new-to-nature C-H transformations, including C-N and C-C bond forming processes. Emerging work with these systems moves us along the ambitious path of building complexity from the ubiquitous C-H bond.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available