Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 57, Issue -, Pages 64-70Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2018.11.002
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Funding
- Academy of Finland [282192, 307415, 312491]
- Sigrid Juselius Foundation
- University of Helsinki (HiLIFE Fellowship)
- Finnish Medical Foundation
- Paulo Foundation
- Alfred Kordelin Foundation
- Maud Kuistila Foundation
- Biomedicum Helsinki Foundation
- Emil Aaltonen Foundation
- Academy of Finland (AKA) [307415, 312491, 307415, 282192, 312491, 282192] Funding Source: Academy of Finland (AKA)
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The formation of neutral lipid filled and phospholipid monolayer engulfed lipid droplets (LDs) from the bilayer of the endoplasmic reticulum (ER) is an active area of investigation. This process harnesses the biophysical properties of the lipids involved and necessitates cooperation of protein machineries in both organelle membranes. Increasing evidence suggests that once formed, LDs keep close contact to the mother organelle and that this may be achieved via several, morphologically distinct and potentially functionally specialized connections. These may help LDs to dynamically respond to changes in lipid metabolic status sensed by the ER. In this review, we will discuss recent progress in understanding how LDs interact with the ER.
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