LibreGrowth: A tumor growth code based on reaction-diffusion equations using shared memory

In recent years, in-silico experimentation within the field of oncological medicine has been intensively investigated with the aim of better understanding tumor dynamics and dose-response relationships in cancer treatments. In a series of previous works, Lujan et al. (2018, 2017, 2016)we described the micro-environmental influence on micro-tumor infiltration patterns through in-silico/in-vitro experimentation. Here we present the latest version of the software utilized for, but not limited to, those studies: LibreGrowth, a libre tumor growth code able to simulate the core growth and peripheral tumor cell infiltration, considering a benign and a malignant stages. We implemented a reaction-diffusion based model, with spatially variable diffusion coefficient, into a three-dimensional domain, using C++ and OpenMP over a GNU/Linux system. LibreGrowth aims to provide a flexible implementation for depicting heterogeneous tissues and infiltration processes, and to shed light in current therapy optimization strategies. (C) 2019 Elsevier B.V. All rights reserved.