Journal
COMPOSITES SCIENCE AND TECHNOLOGY
Volume 175, Issue -, Pages 100-110Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.compscitech.2019.03.012
Keywords
Structural composites; Mechanical properties; Anisotropy
Categories
Funding
- National Natural Science Foundation of China [51573063, 51803062]
- Natural Science Foundation of Guangdong Province [2018A030310379]
- Science and Technology Program of Guangzhou [201804010110]
- National Postdoctoral Program for Innovation Talents [BX201700079]
- China Postdoctoral Science Foundation [2017M620371]
- Foundation for Distinguished Young Talents in Higher Education of Guangdong Province [2017KQNCX001]
- Fundamental Research Funds for the Central Universities, SCUT
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In this study, a strong and tough high-density polyethylene (HDPE)/hydroxyapatite (HA) nanocomposites with bone-analogues structure was successfully prepared via a simple dynamic-oscillation-shear processing method for biomedical application as bone substitute materials. Dynamic-oscillation-shear flow field was applied by self-made loop oscillatory push-pull molding (LOPPM) equipment. The LOPPM-processed HDPE/HA composites exhibited tremendous increase of tensile strength, modulus and toughness up to 95.1 MPa, 4.2 GPa, 58.4 kJ/m(2), respectively, which could be attributed to better dispersion of HA in HDPE matrix and highly ordered shishkebab structure as evident from DSC, SEM, WAXD and SAXS studies. Meanwhile, the formed hierarchical structure not only showed bone-like structure, but also endowed composites with high strength, modulus and toughness, even close to the human cortical bone. Moreover, in vitro cell culture study was performed on NIH-3T3 fibroblast cells to evaluate the biocompatibility of the composites. The results showed that the produced bone substitutes exhibit good biocompatibility. Besides, using a rabbit calvarial defect model, in vivo testing has shown that a strong and stable interface is developed between the composites and the host bone. Overall, we present a facile and green strategy to generate polymer composites with high strength and toughness and the produced LOPPM-processed HDPE/HA polymer nanocomposites have a great potential for use as load-bearing bone substitute in biomedical application.
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