Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 177, Issue -, Pages 204-210Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2019.01.055
Keywords
Drug nanocarrier; Liquid crystal; Decyl betainate chloride; Nanoparticles; pH-responsive
Funding
- Sao Paulo Research Foundation (FAPESP) [2016/03735-0, 2016/25406-5]
- CAPES/MEC
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Dispersed systems of bicontinuous cubic phases, called cubosomes, show a drug release rate faster than those obtained using other liquid-crystalline phases. To minimize side effects associated with the accelerated release of incorporated drugs, compounds may be added in the dispersions to produce systems of slow initial release and then fast release only in the desired action region. This paper addresses the addition of 10.0% (w/w) of decyl betainate chloride (DBC), a cleavable surfactant, into phytantriol/Pluronic-based dispersions to generate lamellar-to-cubic-to-hexagonal phase transitions. Small-angle X-ray scattering (SAXS) was used to analyze the mesophases obtained with the addition of DBC and pH variation. Transmission electron microscopy (TEM) images confirmed the presence of niosomes after the addition of DBC. The niosomes formed in these systems are pH-responsive with lamellar-to-hexosomes transitions at pH >= 7.4. The system investigated herein is gastroresistant presenting potential therapeutic role for controlled release of drugs in neutral or alkaline environments of the organism.
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