Journal
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Volume 17, Issue 13, Pages 2634-2643Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cgh.2019.04.040
Keywords
Crohn's Disease; Classification; Ileal; Colonic
Categories
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [K23DK117058]
- American College of Gastroenterology Junior Faculty Development Award
- Crohn's and Colitis Foundation Career Development Award
- American Gastroenterology Association Research Scholar Award
- Crohn's and Colitis Foundation
- University of California San Diego [KL2 1KL2TR001444]
- NIDDK [RO1 DK108670]
- Wayne and Gladys Valley Foundation
- Chiba University-University of California San Diego Immunology Initiative
- National Institutes of Health [AI079145]
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Crohn's disease (CD) is an inflammatory bowel disease that can involve any region of the gastrointestinal tract. First described in 1932 as terminal ileitis or regional enteritis, it predominately involves the ileum with or without colonic involvement. Isolated colonic CD was first described in 1960 and since then the phenotypic classification of CD has evolved to stratify patients into isolated ileal, ileocolonic, or isolated colonic involvement. In the current review we evaluate the published literature regarding differences in epidemiology, natural history, pathogenesis, response to therapy, and disease monitoring, when stratified by disease location. Based on the available evidence consideration could be given to a new classification for CD, which splits it into ileum dominant (isolated ileal and ileocolonic) and isolated colonic disease. This may allow for a more optimized approach to clinical care and scientific research for CD.
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