Journal
ANNALS OF DERMATOLOGY
Volume 28, Issue 6, Pages 733-739Publisher
KOREAN DERMATOLOGICAL ASSOC
DOI: 10.5021/ad.2016.28.6.733
Keywords
Climbazole; Malassezia species; Piroctone olamine; Seborrheic dermatitis
Categories
Funding
- National Research Foundation of Korea (NRF)
- Ministry of Science, ICT, and Future Planning [NRF-2013R1A1 A2007863]
- Bioderma Laboratoire Dermatologique
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Background: Seborrheic dermatitis (SD) is a multifactorial disease; Ma/assezia species play an important role in its pathogenesis. Objective: We aimed to determine whether a cream containing climbazole/piroctone olamine (C/P cream), antifungal agents with expected efficacy against Malassezia species, could improve SD symptoms. Methods: We instructed 24 patients with mild-to-moderate SD to apply the C/P cream and emollient cream on the right and left sides of the face, respectively, every morning and evening for 4 weeks. The casual sebum level (measured with Sebumeter((R)); Courage & Khazaka Electronic GmbH, Germany) and the extent of erythema (measured with Mexameter((R)); Courage & Khazaka Electronic GmbH) on the face were measured at baseline and after 4 weeks. The minimal inhibitory concentration (MIC) was determined to demonstrate the antifungal activity of the C/P cream. Results: The casual sebum level and erythema were measured at week 4, and the median values demonstrated a quantitative improvement on the C/P cream-treated right side of the face compared to the emollient cream-treated left side. For the C/P cream, the MICs were 0.625, 5, 0.625, and 2.5 mg/ml for Malassezia restricts, M. globosa, M. sympodia/is, and M. slooffiae, respectively. Conclusion: Based on the reduced casual sebum level and extent of erythema, the antifungal activity of C/P cream against Malassezia species seems useful for the treatment of mild to moderate SD.
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