Journal
CLINICAL CANCER RESEARCH
Volume 25, Issue 13, Pages 3750-3752Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-19-0932
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Funding
- NIH Director's HRHR Program [5DP5OD021356-04]
- Robert H. Lurie NCI Cancer Center Support Grant [P30CA060553]
- Developmental Project Award from the Northwestern University SPORE for Translational Approaches to Brain Cancer [P50CA221747]
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Ultrasound-based blood-brain barrier disruption enhances drug delivery. To bypass the human skull, an implantable ultrasound emitter was developed, and proven safe and feasible in a first-in-human trial. Next development steps aim for larger field of disruption, quantification of drug levels, use of various drugs, and ultimately a pivotal trial demonstrating improved outcome.
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