Journal
CIRCULATION RESEARCH
Volume 124, Issue 11, Pages 1568-1583Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.313578
Keywords
biopsy; cardiomyopathies; heart; inflammation; myocarditis
Funding
- Berlin-Brandenburg Center for Regenerative Therapies-BCRT (Bundesministerium fur Bildung und Forschung) [0313911]
- Friede Springer Stiftung
- DZHK
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Myocarditis is generally a mild and self-limited consequence of systemic infection of cardiotropic viruses. However, patients can develop a temporary or permanent impairment of cardiac function including acute cardiomyopathy with hemodynamic compromise or severe arrhythmias. In this setting, specific causes of inflammation are associated with variable risks of death and transplantation. Recent translational studies suggest that treatments tailored to specific causes of myocarditis may impact clinical outcomes when added to guideline-directed medical care. This review summarizes recent advances in translational research that influence the utility of endomyocardial biopsy for the management of inflammatory cardiomyopathies. Emerging therapies for myocarditis based on these mechanistic hypotheses are entering clinical trials and may add to the benefits of established heart failure treatment.
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