Journal
CHEMOSPHERE
Volume 235, Issue -, Pages 403-412Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2019.05.221
Keywords
Climate change; metal(oid)s; Bioaccumulation; Mussels; Oxidative stress; Metabolism
Categories
Funding
- Portuguese Science Foundation (FCT) [SFRH/BD/118582/2016, SFRH/BD/108535/2015]
- FSE
- Programa Operacional Capital Humano (POCH) e da Uniao Europeia
- national funds (OE), through FCT - Fundacao para a Ciencia e a Tecnologia, I.P.
- project BISPECIAI: BlvalveS under Polluted Environment and Climate chAnge - FEDER, through COMPETE2020 - Programa Operacional Competitividade e Internacionalizacao (FOCI) [PTDC/CTA-AMB/28425/2017 (POCI-01-0145-FEDER-028425)]
- national funds (OE), through FCT/MCTES
- CESAM [UID/AMB/50017/2019]
- FEDER within the PT2020 Partnership Agreement
- Compete 2020
- Spanish Ministry of Economy, Industry and Competitivity: AimCost project [CGL2016-76332-R MINECO/FEDER/UE]
- CYTED [419RT0578]
- FCT/MEC
- Fundação para a Ciência e a Tecnologia [SFRH/BD/108535/2015] Funding Source: FCT
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Mussels, such as the marine bivalve Mytilus galloprovincialis are sentinels for marine pollution but they are also excellent bioindicators under laboratory conditions. For that, in this study we tested the modulation of biochemical responses under realistic concentrations of the toxic metal Lead (Pb) in water for 28 days under different conditions of salinity and temperature, including control condition (temperature 17 +/- 1.0 degrees C and salinity 30 +/- 1.0) as well as those within the range expected to occur due to climate change predictions (+/- 5 in salinity and + 4 degrees C in temperature). A comprehensive set of biomarkers was applied to search on modulation of biochemical responses in terms of energy metabolism, energy reserves, oxidative stress and damage occurrence in lipids, proteins as well as neurotoxicity signs. The application of an integrative Principal Coordinates Ordination (PCO) tool was successful and demonstrated that Pb caused an increase in the detoxification activity mainly evidenced by glutathione S-transferases and that the salinities 25 and 35 were, even in un-exposed mussels, responsible for cell damage seen as increased levels of lipid peroxidation (at salinity 25) and oxidised proteins (at salinity 35). (C) 2019 Elsevier Ltd. All rights reserved.
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