Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 43, Pages 10069-10073Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201902298
Keywords
azolium; catalysis; conjugate addition; halogen bonding; Lewis bases
Categories
Funding
- National Institutes of Health [NIGMS R01-GM073072] Funding Source: Medline
Ask authors/readers for more resources
A method for the synthesis of iodinated imidazolium and triazolium N-heterocyclic halogen-bond-donor catalysts has been developed. This approach was applied to the synthesis of a variety of 1,2,4-triazolium salts to prepare a series of novel chiral halogen-bond-donor catalysts. The counterions of the iodinated triazoliums can be readily exchanged with chiral and achiral non-coordinating counterions to produce unique scaffolds. Their ability to promote/catalyse a conjugate addition reaction with indole was investigated. Through these initial studies, a set of general guidelines and considerations for the application of these halogen-bond donors in organocatalysis have been established.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available