Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 45, Issue 1, Pages 195-209Publisher
SPRINGER
DOI: 10.1007/s10439-016-1607-5
Keywords
Bioink; Hydrogel; Vascularization; Heart valve; Organ Bioprinting
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Funding
- Mary & Dick Holland Regenerative Medicine Program
- Nebraska Research Initiative
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3D bioprinting is a group of rapidly growing techniques that allows building engineered tissue constructs with complex and hierarchical structures, mechanical and biological heterogeneity. It enables implementation of various bioinks through different printing mechanisms and precise deposition of cell and/or biomolecule laden biomaterials in predefined locations. This review briefly summarizes applicable bioink materials and various bioprinting techniques, and presents the recent advances in bioprinting of cardiovascular tissues, with focusing on vascularized constructs, myocardium and heart valve conduits. Current challenges and further perspectives are also discussed to help guide the bioink and bioprinter development, improve bioprinting strategies and direct future organ bioprinting and translational applications.
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