Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 18, Pages 4673-4677Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201900409
Keywords
3-aminooxindole; methyleneindolinone; one-pot synthesis; polycyclic spirooxindole; ring-opening reactions
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Funding
- National Natural Science Foundation of China [21576296, 21676302, 21776318, 81703365]
- Natural Science Foundation of Hunan Province [2017JJ3401]
- Central South University
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One-pot ring-opening/ring-closure process of combining methyleneindolinone with 3-aminooxindole has been developed in this work. Novel polycyclic spirooxindoles were efficiently assembled under mild conditions in high yields (up to 95%) with moderate to good diastereoselectivities (up to > 95:5 d.r.) through simple filtration.
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