Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 17, Pages 4491-4495Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201806239
Keywords
Barbier; cobalt; Mannich; reductive coupling; zinc
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Funding
- CNRS
- University Paris-Est
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The reductive Barbier coupling of aromatic halides and electrophiles has been achieved using a CoBr2/1,10-phenanthroline catalytic system and over stoichiometric amounts of zinc. The reaction displayed a broad scope of substrates, including (hetero)aryl chlorides as pro-nucleophiles and aldehydes or imines as electrophiles, leading to diarylmethanols and diarylmethylamines in moderate to excellent yields, respectively.
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