Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 19, Pages 4946-4950Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201900743
Keywords
chemoselectivity; flow microreactor; functionalized ketones; organic synthesis; organolithium
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Funding
- MEXT [15H05849, 26288049, 26220804, 25220913, 17865428]
- AMED [18061567]
- Japan Science and Technology Agency's (JST) A-step program [18067420]
- Ogasawara Foundation for the Promotion of Science Engineering
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Synthesis of ketones containing various functional groups from acid chlorides bearing electrophilic functional groups and functionalized organolithiums was achieved using a flow microreactor system. Extremely fast mixing is important for high chemoselectivity.
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