Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 55, Issue 4-5, Pages 324-332Publisher
SPRINGER
DOI: 10.1007/s10593-019-02461-1
Keywords
1,2-amino alcohols; aziridines; epoxides; morpholines; 1; 4-oxazinanes
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Funding
- SAIA
- National Scholarship Programme of the Slovak Republic
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The morpholine (1,4-oxazinane) motif attracted significant attention due to its widespread availability in natural products and biologically relevant compounds. This review describes recent advances in the synthesis of morpholines and their carbonyl-containing analogs from 1,2-amino alcohols, aziridines, epoxides, and related compounds. Special attention is paid to the syntheses performed in a stereoselective manner and using transition metal catalysis. Selected works published since 2013 are covered.
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