4.5 Article

Multi-scale Modeling in Clinical Oncology: Opportunities and Barriers to Success

Related references

Note: Only part of the references are listed.
Review Biochemical Research Methods

Multiscale modelling in immunology: a review

Antonio Cappuccio et al.

BRIEFINGS IN BIOINFORMATICS (2016)

Review Biology

Tissue constructs: platforms for basic research and drug discovery

Elliot L. Elson et al.

INTERFACE FOCUS (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

Radiomics: Images Are More than Pictures, They Are Data

Robert J. Gillies et al.

RADIOLOGY (2016)

Article Pharmacology & Pharmacy

Good Practices in Model-Informed Drug Discovery and Development: Practice, Application, and Documentation

S. F. Marshall et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2016)

Article Oncology

Toward a Science of Tumor Forecasting for Clinical Oncology

Thomas E. Yankeelov et al.

CANCER RESEARCH (2015)

Review Pharmacology & Pharmacy

Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development: A Pharmaceutical Industry Perspective

H. M. Jones et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Biochemical Research Methods

Role of Chemical Reactivity and Transition State Modeling for Virtual Screening

Muthukumarasamy Karthikeyan et al.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2015)

Review Pharmacology & Pharmacy

Computational systems biology approaches to anti-angiogenic cancer therapeutics

Stacey D. Finley et al.

DRUG DISCOVERY TODAY (2015)

Review Medicine, Research & Experimental

Targeting cancer with kinase inhibitors

Stefan Gross et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

News Item Multidisciplinary Sciences

'Organs-on-chips' go mainstream

Sara Reardon

NATURE (2015)

Review Oncology

Simulating cancer growth with multiscale agent-based modeling

Zhihui Wang et al.

SEMINARS IN CANCER BIOLOGY (2015)

Article Biochemical Research Methods

A Multiscale Model Evaluates Screening for Neoplasia in Barrett's Esophagus

Kit Curtius et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

Article Biochemical Research Methods

Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model

Lindsay Wendel Clegg et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

Article Pharmacology & Pharmacy

Systems pharmacology approaches for optimization of antiangiogenic therapies: challenges and opportunities

Satish Sharan et al.

FRONTIERS IN PHARMACOLOGY (2015)

Article Pharmacology & Pharmacy

Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology: Challenges and Opportunities

K. Venkatakrishnan et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2015)

Article Biochemical Research Methods

Characterization of p38 MAPK isoforms for drug resistance study using systems biology approach

Huiming Peng et al.

BIOINFORMATICS (2014)

Review Cardiac & Cardiovascular Systems

Cardiac Tissue Engineering State of the Art

Marc N. Hirt et al.

CIRCULATION RESEARCH (2014)

Editorial Material Pharmacology & Pharmacy

Assessment of Tumor Growth Inhibition Metrics to Predict Overall Survival

L. Claret et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)

Review Oncology

Determining the optimal dose in the development of anticancer agents

Ron H. J. Mathijssen et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2014)

Article Oncology

Quantitative multimodality imaging in cancer research and therapy

Thomas E. Yankeelov et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2014)

Article Multidisciplinary Sciences

Global Dormancy of Metastases Due to Systemic Inhibition of Angiogenesis

Sebastien Benzekry et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

The Anomalous Diffusion of a Tumor Invading with Different Surrounding Tissues

Chongming Jiang et al.

PLOS ONE (2014)

Article Multidisciplinary Sciences

Timing and heterogeneity of mutations associated with drug resistance in metastatic cancers

Ivana Bozic et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Pharmacology & Pharmacy

Implementation of Quantitative and Systems Pharmacology in Large Pharma

S. A. G. Visser et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2014)

Article Mathematics, Applied

POPULATIONAL ADAPTIVE EVOLUTION, CHEMOTHERAPEUTIC RESISTANCE AND MULTIPLE ANTI-CANCER THERAPIES

Alexander Lorz et al.

ESAIM-MATHEMATICAL MODELLING AND NUMERICAL ANALYSIS-MODELISATION MATHEMATIQUE ET ANALYSE NUMERIQUE (2013)

Article Oncology

Effect of Tumor Microenvironment on Tumor VEGF During Anti-VEGF Treatment: Systems Biology Predictions

Stacey D. Finley et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Article Engineering, Biomedical

A mechanically coupled reaction-diffusion model for predicting the response of breast tumors to neoadjuvant chemotherapy

Jared A. Weis et al.

PHYSICS IN MEDICINE AND BIOLOGY (2013)

Article Multidisciplinary Sciences

Defining principles of combination drug mechanisms of action

Justin R. Pritchard et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Cell Biology

Clinically Relevant Modeling of Tumor Growth and Treatment Response

Thomas E. Yankeelov et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Engineering, Biomedical

Multiscale Models of Breast Cancer Progression

Anirikh Chakrabarti et al.

ANNALS OF BIOMEDICAL ENGINEERING (2012)

Article Pharmacology & Pharmacy

Fundamentals of Population Pharmacokinetic Modelling

Catherine M. T. Sherwin et al.

CLINICAL PHARMACOKINETICS (2012)

Article Pharmacology & Pharmacy

Fundamentals of Population Pharmacokinetic Modelling

Tony K. L. Kiang et al.

CLINICAL PHARMACOKINETICS (2012)

Review Cell Biology

Cellular modeling of cancer invasion: Integration of in silico and in vitro approaches

Yoonseok Kam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

A systematic modeling study on the pathogenic role of p38 MAPK activation in myelodysplastic syndromes

Huiming Peng et al.

MOLECULAR BIOSYSTEMS (2012)

Article Mathematics, Applied

SYSTEM IDENTIFICATION IN TUMOR GROWTH MODELING USING SEMI-EMPIRICAL EIGENFUNCTIONS

Thierry Colin et al.

MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES (2012)

Article Medicine, General & Internal

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Marco Gerlinger et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Proceedings Paper Computer Science, Interdisciplinary Applications

A Study on Cheminformatics and its Applications on Modern Drug Discovery

B. Firdaus Begam et al.

INTERNATIONAL CONFERENCE ON MODELLING OPTIMIZATION AND COMPUTING (2012)

Article Oncology

2011: the immune hallmarks of cancer

Federica Cavallo et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2011)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Multidisciplinary Sciences

Drug Inhibition Profile Prediction for NFκB Pathway in Multiple Myeloma

Huiming Peng et al.

PLOS ONE (2011)

Article Computer Science, Artificial Intelligence

Extrapolating glioma invasion margin in brain magnetic resonance images: Suggesting new irradiation margins

Ender Konukoglu et al.

MEDICAL IMAGE ANALYSIS (2010)

Article Medicine, Research & Experimental

Toward a VPH/Physiome ToolKit

Alan Garny et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2010)

Article Biochemical Research Methods

Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

Roger L. Chang et al.

PLOS COMPUTATIONAL BIOLOGY (2010)

Review Oncology

Dissecting cancer through mathematics: from the cell to the animal model

Helen M. Byrne

NATURE REVIEWS CANCER (2010)

Review Engineering, Biomedical

Multiscale Models of Angiogenesis

Amina A. Quitub et al.

IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE (2009)

Editorial Material Chemistry, Multidisciplinary

Drug targeting and tumor heterogeneity

You Han Bae

JOURNAL OF CONTROLLED RELEASE (2009)

Review Multidisciplinary Sciences

Multiscale Modeling of Form and Function

Adam J. Engler et al.

SCIENCE (2009)

Article Biochemistry & Molecular Biology

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis

Birgit Schoeberl et al.

SCIENCE SIGNALING (2009)

Article Medicine, Research & Experimental

Agent-based models in translational systems biology

Gary An et al.

WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE (2009)

Review Biotechnology & Applied Microbiology

Predicting drug side-effects by chemical systems biology

Nicholas P. Tatonetti et al.

GENOME BIOLOGY (2009)

Article Mathematical & Computational Biology

Essential operating principles for tumor spheroid growth

Jesse A. Engelberg et al.

BMC SYSTEMS BIOLOGY (2008)

Article Pharmacology & Pharmacy

Development of translational pharmacokinetic-pharmacodynamic models

D. E. Mager et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2008)

Review Biochemistry & Molecular Biology

Network pharmacology: the next paradigm in drug discovery

Andrew L. Hopkins

NATURE CHEMICAL BIOLOGY (2008)

Article Multidisciplinary Sciences

Age-specific incidence of cancer: Phases, transitions, and biological implications

Rafael Meza et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biology

An age-and-cyclin-structured cell population model for healthy and tumoral tissues

Fadia Bekkal Brikci et al.

JOURNAL OF MATHEMATICAL BIOLOGY (2008)

Article Pharmacology & Pharmacy

Model-based drug development

R. L. Lalonde et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)

Article Biochemistry & Molecular Biology

Systems biology and combination therapy in the quest for clinical efficacy

Jonathan B. Fitzgerald et al.

NATURE CHEMICAL BIOLOGY (2006)

Article Mathematics, Applied

Mathematical methods and tools of kinetic theory towards modelling complex biological systems

A Bellouquid et al.

MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES (2005)

Article Biology

A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion

ARA Anderson

MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA (2005)

Article Multidisciplinary Sciences

Multistage carcinogenesis and the incidence of colorectal cancer

EG Luebeck et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Mathematics, Applied

On the closure of mass balance models for tumor growth

D Ambrosi et al.

MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES (2002)

Article Chemistry, Medicinal

Pharmacokinetics and its role in small molecule drug discovery research

GR Jang et al.

MEDICINAL RESEARCH REVIEWS (2001)