Journal
ANNALS OF BIOMEDICAL ENGINEERING
Volume 45, Issue 1, Pages 297-305Publisher
SPRINGER
DOI: 10.1007/s10439-016-1648-9
Keywords
Extrusion printing; PLGA; Alginate; Controlled delivery; Differential delivery; Composite materials
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Funding
- NSF [1462232, CAREER 1349716]
- GAP Award from The University of Iowa
- NIH [1R21DE024206-01A1]
- Center for Biocatalysis and Bioprocessing Graduate Fellowship
- Lyle and Sharon Bighley Professorship
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1624515, 1600118] Funding Source: National Science Foundation
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Controlled drug delivery systems, that include sequential and/or sustained drug delivery, have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. In this study, with the aid of 3D printing technology, a novel drug delivery device was fabricated and tested to evaluate sequential delivery functionality. With an alginate shell and a poly(lactic-co-glycolic acid) (PLGA) core, the fabricated tubes displayed sequential release of distinct fluorescent dyes and showed no cytotoxicity when incubated with the human embryonic kidney (HEK293) cell line or bone marrow stromal stem cells (BMSC). The controlled differential release of drugs or proteins through such a delivery system has the potential to be used in a wide variety of biomedical applications from treating cancer to regenerative medicine.
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