Journal
CHEMCATCHEM
Volume 11, Issue 13, Pages 3000-3003Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.201900602
Keywords
para-hydrogenation; PHIP; aqueous media; transition metals; homogeneous catalysis
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Funding
- National Research, Development and Innovation Office of Hungary [NKFI PD115535, NKFI FK128333]
- EU - European Regional Development Fund [GINOP-2.3.2-15-2016-00008, GINOP-2.3.3-15-2016-00004]
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Catalytic hydrogenations with para-H-2 may lead to strong para-hydrogen induced polarization (PHIP) and the hyperpolarized probe molecules may enable the application of the Magnetic Resonance Imaging (MRI) diagnostic modality for metabolism imaging. The use of water as a solvent for para-hydrogenation reactions is very challenging due to the fast exchange between the catalytically active metal hydrides and the water protons and also because of the low hydrogen solubility in water. Here we report that several water-soluble Rh(I)- and Ir(I)-complexes with N-heterocyclic carbene (NHC) and/or tertiary phosphine ligands efficiently catalyze the synthesis of hyperpolarized compounds by para-hydrogenation in aqueous media.
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