Journal
CELLULAR IMMUNOLOGY
Volume 340, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2019.103922
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Funding
- National Science Fund for Distinguished Young Scholars [31525008]
- National Natural Science Foundation of China [81830051, 81330072, 31370863]
- NIH-NSFC collaborative grant [81161120417]
- Shanghai Rising Star program [10QA1407900]
- SMCST [14JC1406100]
- Science and Technology Commission of Shanghai [17DZ2260100]
- [16XD1403800]
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T cells play critical roles in immune responses to pathogens, autoimmunity, and antitumor immunity. During the past few decades, increasing numbers of studies have demonstrated the significance of protein ubiquitination in T cell-mediated immunity. Several E3 ubiquitin ligases and deubiquitinases (DUBs) have been identified as either positive or negative regulators of T cell development and function. In this review, we mainly focus on the roles of DUBs (especially ubiquitin-specific proteases (USPs)) in modulating T cell differentiation and function, as well as the molecular mechanisms. Understanding how T cell development and function is regulated by ubiquitination and deubiquitination will provide novel strategies for treating infection, autoimmune diseases, and cancer.
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